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Nonetheless, the mechanism behind this is still unknown

100 Despite the promising effect of CQ, 100 a recent phase I/II clinical trial combining HCQ with TMZ and radiation therapy, in patients with newly diagnosed GBM showed that the maximum tolerated dose of HCQ was unable to consistently inhibit autophagy and that dose-limiting toxicity prevented the possibility of moving to higher doses of HCQ

66,70 The primary metabolites of 8-THC are the euphoric 11-OH-8-THC, produced by cytochrome P450 (CYP) enzyme hydroxylation, and inactive metabolite 8-THCCOOH(73, 7375)